Recently, in Korea, we have encountered difficulties in the treatment of gonococcal infections because Neisseria gonorrhoea has become increasingly less sensitive to penicillins and the most of other antibiotics.
Although Penicillinase Producing Neisseria Gonorrlioeae (PPNG) strains have spread to the most of the world, its prevalence varies from region to region. In 1981 a sudden and unusually steep increase of PPNG strains had occured in Korea. In this study bacteriological cliaracteristics of circulating Neisseria gonorrhoeae are evaluated.
Plasmid analysis, serological classification and auxotyping were carried out on 82 strains of Neisseria gonorrhoeae (PPNG: 41, non-PPNG: 41) isolated at the VD Clinic of Choong-Ku Public Health Center in Seoul during 8 months period from February to October 1982. Plamid analysis showed that 2.6 mega daltons plasmid was detected from all PPNG and non-PPNG strains, 4.4 mega daltons plasmid from only, and every, PPNG strains and 24.5 mega daltons plasmid was detected from 40 (97.6%) of 41 PPNG strains and 26 (63.410) of 41 non-PPNG strains. The serogroup of gonococcal isolates was limited to W II type. The most common auxotype of gonococcal isolates was zero or wild type strain (PPNG: 89.7%, non-PPNG: 70%).
No bacteriological charcteristics responsible for unusually steep increase of PPNG strains in Seoul in 19131 is found suggesting that the steep increase of PPNG strain in 19131 in Seoul had occured some other unknown factor or factors other than bacteriological one.
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